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The Jorge 2026 study found that GLP-1 receptor agonists were associated with reduced progression of kidney disease in lupus patients, including those with lupus nephritis

doi: 10.1016/j.jamcollsurg.2019.04.014 54

Typically, after two to four weeks of consistent use, most people experience a more pronounced and sustained reduction in hunger

doi: 10.1148/radiographics.22.5.g02se061023

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Here is what to watch for: Gradual or persistent weight loss despite maintaining a reasonable appetite Chronic or recurring diarrhoea that does not fully resolve with standard treatment Reduced appetite or inconsistent interest in food Lethargy and reduced energy that does not match the dogs age or activity level A dull, dry, or poorly conditioned coat that does not reflect the diet being offered Slow recovery from illness or repeated episodes of digestive upset In more advanced cases, neurological signs such as weakness, unsteady gait, or reduced responsiveness In many long-term rescue cases, vitamin B12 deficiency has been present for months before the dog receives proper assessment